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As science advances, preserved samples and their derived data will be key to unlocking the complexities of biology and human health. Cache is developing scalable, sustainable, and standardized methods to enable ambient transport and storage of samples like cell-free DNA (cfDNA) and RNA.

Source: MIT News

Cache's enabling technology was developed to address fundamental limits in the life sciences:

• Improving Stability: Advances in science and technology depend on reliable preservation. We are developing solutions that support real-world applications from biomedical research to environmental sampling.
• Enhancing Standardization: cold chain logistics and time-sensitive sample preparation methods contribute to pre-analytical variability. Operating at room temperature eliminates freeze-thaw considerations and controls for a key variable between tests/batches.
• Advancing Sustainability: Ambient preservation reduces waste, optimizes resources, and improves efficiency. Say goodbye to dependencies on freezers/dry ice and hello to efficiently utilized space and seamless sample management.
• Unlocking Scalability: As industries grow, so do their preservation needs. Our technologies are designed to grow with labs and support large-scale operations, ensuring consistent quality and efficiency.

Our approach is built on rigorous research and innovation. Explore some of the key publications and conference presentations detailing our advancements:

• ACS Applied Materials & Interfaces (Banal & Bathe, 2021)
• Nature Materials (Banal et al. 2021)
• ACMG 2024 (Abbas-Aghababazadeh et al. 2024)
• ISBER Annual Meetings & Exhibits (Organick et al. 2024)
• Cell Trends in Genetics 2025 (Ashley 2025)
• SLAS 2025 (Pierce et al. 2025)
• AGBT 2025 (Coming Soon)

I. Research Use Only (RUO) Demo Kits

We will soon be offering our Caching technology to anyone in the world! Apply now for a chance to receive a kit, complete with training and instructions. Your insights will shape the future of biopreservation—helping us refine our technology while giving you a firsthand look at the cost savings and extended stability our solutions provide. Check out a video of our manual protocol here.

Please note: that we have concluded our first cycle of feedback before the kit is commercially available. Apply now to join our waiting list for the next time the kits will be available!

II. Pilot Program for Automated System

Looking to streamline biopreservation at scale? Our team will work with you to implement high-throughput Caching in plates rather than tubes, seamlessly integrating with your existing extraction and library preparation workflows. Check out a video of our automated protocol on a liquid handler here.

III. Impact Calculator

Competing in the My Green Lab Freezer Challenge? Curious about the sustainability benefits of switching to Cache’s room-temperature storage? Use our impact calculator to estimate potential reductions in carbon emissions and energy consumption.